Applications

We at 3Scan are open to any and all research projects interested in analyzing 3D structures. Whether it be fluorescent dyes on tumors or fiber tracing in aerospace composites, there’s a staff member willing and able to accommodate your project.

Our technology really shines in applications requiring high throughput of large volume samples. The new KESM can process up to 1 cm3hr of any tissue sample with perfect registration between slices and multiple imaging modalities available. With this capability, a wide variety of structural information can be captured, manipulated, and analyzed to provide insights into your research problems.

Below are a research areas we consider particularly promising.

Histology

The field of biopsies is constrained by a balance between quick analysis required during live biopsies and the critical analysis needed for accurate discovery. Our microscope can quickly process a biopsy and generate a 3D representation while simultaneously comparing the structure with prior recorded samples. Such a tool offers a much wider set of information to a histologist in shorter time, and adds in machine aided discovery to the process.

Research interests in other histology areas include analyzing the structure of cancerous tissues, processing diseased neural tissue to develop systematic structural indicators, and examining drug effects on tissue morphology. One example project would be imaging how well fluorescent stains cover a tissue area by switching between fluorescence imaging and contrast imaging with each slice and building a coverage map.

Neuroscience

3Scan very much wants to continue its roots in neuroscience pursuing connectomics and neurobiology work. Areas of particular interest are network complexity, connectivity, patterning, whole brain connectivity, and correlation between structure and function, particularly in learning and neuron complexity.

Further, we have significant experience in sample preparation for neural tissue. Protocols have been developed and published in JoVE (see our movies page), and subsequently improved, quicker techniques are being developed to take samples from live animals through to processed data.

Composite Materials Science

Another area of interest is the development of quality control and analysis techniques for the carbon fiber industry. Current techniques do not portray the full picture of material, instead giving insight into only a small surface depth of any composite using ultrasound techniques. With the KESM, we can sample large volumes of carbon fiber composites and accurately describe defects and imperfections in the material.

In the future we hope to test carbon fiber failures, detailing how delaminations happen, and exploring manufacturer defects. And as research in self-healing carbon fiber composites continues to develop, we can provide a critical tool for gaining an eye into the material’s inner workings.

Capabilities

Specifications of our microscope to give scope to projects

Min.Max.
Resolution500nm2µm
Volume1mm35cm3
Speed1slicesec1cm38hrs
Data1TBcm3
Fluorescence Available depending on stain

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